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Half-life elimination is graphically represented with elimination curves that track the amount of a drug in the body over time, typically with time on the independent axis and drug plasma concentration on the dependent axis, as shown in Figure 1. This article will focus on first-order half-life elimination as it is the most frequently encountered in clinical practice. In contrast, a few drugs follow zero-order elimination in which the drug amount decreases by a constant amount over time regardless of initial concentration (i.e., ethanol). Most clinically relevant drugs tend to follow first-order pharmacokinetics that is, their drug-elimination rates are proportional to plasma concentrations. The characteristic decreases of drugs over time have long been studied in a field known as pharmacokinetics and are depictable by basic differential equations. Different drugs have different half-lives however, they all follow this rule: after one half-life has passed, 50% of the initial drug amount is removed from the body. Understanding the concept of half-life is useful for determining excretion rates as well as steady-state concentrations for any specific drug. Continued abuse of our services will cause your IP address to be blocked indefinitely.Half-life in the context of medical science typically refers to the elimination half-life. The definition of elimination half-life is the length of time required for the concentration of a particular substance (typically a drug) to decrease to half of its starting dose in the body. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.
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